| Benedict Cumberbatch (Sherlock Holmes) |
| Martin Freeman (Le docteur John Watson) |
| Rupert Graves (Lestrade) |
| Paul Chequer (L'inspecteur Dimmock) |
| Zoe Telford (Sarah) |
| Jack Bence (Raz) |
| Gemma Chan (Soo Lin Yao) |
| Vinette Robinson (Le sergent Sally Donovan) |
| Tanya Moodie (Ella) |
| Bertie Carvel (Sebastian Wilkes) |
| Siobhan Hewlett (Helen) |
| Al Weaver (Andy Galbraith) |
| Una Stubbs (Madame Hudson) |
| Victoria Wicks (Margaret Patterson) |
| Loo Brealey (Molly Hooper) |
| William Scott-Masson (Sir Jeffrey Patterson) |
| James Duncan (Jimmy) |
| Daniel Percival (Eddie van Coon) |
| Howard Coggins (Brian Lukis) |