| Jamie Foxx (Nathaniel Ayers) |
| Robert Downey Jr. (Steve Lopez) |
| Catherine Keener (Mary Weston) |
| Tom Hollander (Graham Claydon) |
| Lisagay Hamilton (Jennifer Ayers) |
| Nelsan Ellis (David Carter) |
| Rachael Harris (Leslie Bloom) |
| Stephen Root (Curt Reynolds) |
| Lorraine Toussaint (Flo Ayers) |
| Justin Martin (Nathaniel jeune) |
| Kokayi Ampah (Bernie Carpenter) |
| Patrick Tatten (Paul Jr.) |
| Susane E. Lee (Marisa) |
| Marcos de Silvas (Mayor Villaraigosa) |
| Ilia Volok (Harry Barnoff) |
| Michael Bunin (Adam Crane) |
| Michael Nowak |
| Jena Malone (Cheery la scientifique) |
| Octavia Spencer |
| David Jean Thomas |
| Lemon Anderson (Oncle Tommy) |
| Kevin Michael Key |
| Moya Brady |
| Orlando Ashley |
| Artel Great (Leon) |
| J. J. Boone |
| Annie McKnight |
| Bernadette Speakes |
| Lee Anna Levin (Leeann) |
| Steve Foster (Steve) |
| Vivian Terresa George (Teresa) |
| Kevin Cohen (KK) |
| Courtney Andre (Courtney) |
| Teri Hughes |
| Linda Harris (Linda) |
| Albert Olson (Bam Bam) |
| Melissa Black (Melissa) |
| Valarie Hudspeth (Mama Grouch) |
| Darryl Black Sr. (Darryl) |
| Kiana Parker (Kiana) |
| Hazard Banner (Hazard) |
| Russell Brown (Russell) |
| Kenneth Henry (Simone) |
| Jacqueline Sue West (Jackie) |
| Joyre Manuel (Ashley) |
| Lorinda Hawkins (La chanteuse) |
| Annette Valley (Annette) |
| Patrick Kelly (Patrick) |
| Quiana Farrow (Quiana) |
| Tony Genaro |
| Charlie Weirauch |
| Wayne Lopez |
| Joe Hernandez-Kolski |
| Noel G. |
| Paul Cruz |
| Wil Garret |
| Halbert Hernandez |
| Alejandro Patiño |
| Karole Selmon |
| Rob Nagle (Neil) |
| Patricia Place |
| Ralph Cole Jr. |
| Gladys Peters |
| Palma Lawrence Reed |
| Isabel Hubmann |
| Bonita Jefferson |
| Eshana O'Neal |
| Myia Hubbard (Jennifer Ayers jeune) |
| Iyanna Newborn (Miss Little John) |
| Bronwyn Hardy |
| Troy Blendell |
| Nick Nervies (Le fils de Jennifer) |
| Paul Norwood |
| Don Abernathy |
| Justin Aguila |
| Rio Ahn |
| Meggan Anderson |
| Julia Anna Barrios |
| Laura Beckner |
| Matt Besser |
| Elena Nikitina Bick |
| Kimberly Bishop |
| Pete Brown |
| Joshua Cabrera |
| Gerry Carbajal |
| Jason Cekanski |
| Mike Cochrane |
| David Cohen |
| Ingrid Coree |
| Bridget Coulter |
| Doby Daenger |
| Youlanda Davis |
| Aurelius DiBarsanti |
| Bonita Dorssom |
| Johnny Drocco |
| Windy Duncan |
| Paul Edney |
| S. Zev Esquenazi (Le sgt Hendrickson) |
| Angela Featherstone |
| Lauren E. Gates |
| Marissa Ghavami |
| Paul Grace |
| Alan Gray |
| Paul Greenberg |
| Nancy Guerriero |
| Lejla Hadzimuratovic |
| Justin Rodgers Hall (Le sgt Harris) |
| Richard Hansen (Un policier) |
| Terri Hughes |
| Pete Ilarius |
| Chasey James |
| Paul Jeans |
| Christopher Karl Johnson |
| Siso Kamburov |
| Edward Kiniry-Ostro (Craig) |
| Adam Knapp |
| Francesca Kortesmaki |
| Therese Kortesmaki |
| Kitty Kreidler |
| Heather La Bella |
| Hallie Lambert |
| Michela Lansing |
| Kirsten Lea |
| Karen Levine (Jena Malone) |
| Janaya Logan |
| Wally Lozano |
| Patrick MacKellan |
| Michael Maddigan |
| Ricky Marciano (Un policier) |
| Lauren Suzanne Martin |
| Jennifer McGraw |
| Paul McMichael |
| George Meyers (Un policie) |
| Gabriel Morales |
| Samantha Nunley |
| Joel Pargman |
| Tiffany Pulvino |
| Franklin Ruehl |
| Paul Hobson Sadler |
| Esa-Pekka Salonen |
| Jules Sanchez |
| Sharon Savene (Un policier) |
| Thierry Segall (La rock star française) |
| Eric Shackelford |
| Holly Sherman |
| Gary Sievers |
| Kortnee Simmons |
| Arne Starr |
| Jeff Sutherland |
| April Marie Thomas |
| Gina Tleel (La prof de musique) |
| Karmyn Tyler |
| Maggie Wagner (Mme Villaraigosa) |
| Troy Williams (Un policier à l'hôpital) |