| Morgan Freeman (Theodore Joadson) |
| Nigel Hawthorne (Martin van Buren) |
| Anthony Hopkins (John Quincy Adams) |
| Djimon Hounsou (Cinque) |
| Matthew McConaughey (Roger Baldwin) |
| David Paymer (Le secrétaire d'Etat Forsyth) |
| Pete Postlethwaite (Holabird) |
| Stellan Skarsgård (Lewis Tappan) |
| Razaaq Adoti (Yamba) |
| Abu Bakaar Fofanah (Fala) |
| Anna Paquin (La reine Isabelle) |
| Tomas Milian (Calderon) |
| Chiwetel Ejiofor (L'enseigne Covey) |