| Paul Michael Glaser (David Starsky) |
| David Soul (Ken Hutchinson) |
| Janet Margolin (Le Dr. Judith Kaufmann) |
| Bernie Hamilton (Le capitaine Dobey) |
| Antonio Fargas (Huggy «les bons tuyaux») |
| Al Ruscio (Roper) |
| Jean Allison (Helen Yeager) |
| Frank Marth (Le docteur Meredith) |
| Alex Rocco (Thomas Callendar) |
| Walter Mathews (Jake Donner) |
| Paul Kent (Le lieutenant Anderson) |
| Patrick Laborteaux (Richie Yeager) |
| John Alvin |
| David Milton (Un docteur) |
| Natalie Norwick (Virginia Donner) |
| Linda Dano (Janet Mayer) |
| Dee Wallace (Carol Wade) |
| Mike Lane (Eddie) |
| Meeno Peluce (Guy Mayer) |
| Rosalind Cash (Sheila) |
| Tara Tyson (Gwen Larson) |
| Jason Ronard (Coop) |
| Al White (Franklin) |
| Nancy McKeon (Vikki Mayer) |
| Penelope Sudrow (Ellen) |