| James Stewart (George Bailey) |
| Donna Reed (Mary Hatch Bailey) |
| Lionel Barrymore (M. Henry F. Potter) |
| Thomas Mitchell (William "L'oncle Billy" Bailey) |
| Henry Travers (Clarence Oddbody) |
| Beulah Bondi (Mme Bailey) |
| Frank Faylen (Ernie Bishop, le chaffeur de taxi) |
| Ward Bond (Bert, le flic) |
| Gloria Grahame (Violet Bick) |
| H. B. Warner (M. Gower) |
| Todd Karns (Harry Bailey) |
| Samuel S. Hinds (Peter 'Pa' Bailey) |
| Mary Treen (La cousine Tilly) |
| Frank Albertson (Sam Wainwright) |
| Virginia Patton (Ruth Dakin Bailey) |
| Jean Acker |